Liping Wei, Ph.D.

Investigator, NIBS, Beijing, China

Phone: 010-80726688-8610 010-80706016

Fax： 010-80706019

E-mail：weiliping@nibs.ac.cn

Education

2000	Ph.D., Medical Information Sciences（now renamed Biomedical Informatics）, Stanford University School of Medicine, Stanford, California, USA
1994	M.Sc., Applied Mathematics, Brown University, Providence, Rhode Island, USA
1993	Undergraduate, Radio Electronics (now renamed Electrical Engineering and Information Sciences), University of Science and Technology of China, Hefei, Anhui, China

Professional Experience

2011-	Investigator, National Institute of Biological Sciences, Beijing, China
2004-	Professor, Director, Center for Bioinformatics, Peking University; Associate Director, National Laboratory of Protein Engineering and Plant Genetic Engineering, Beijing, China
2002-2004	Consulting Assistant Professor of Medicine (Biomedical Informatics), Stanford University School of Medicine, Stanford, California, USA
2001-2003	Co-founder, Chief Scientific Officer, Nexus Genomics, Inc., Mountain View, California, USA

Professional Services and Honors

2010-2013	Member of the Board of Directors, International Society of Computational Biology (ISCB) (selected by worldwide election by members of ISCB, the largest international society for bioinformatics and computational biology with members in over 70 countries.)
2009-	Member of the Public Library of Science (PLoS) International Advisor Group
2010	National Outstanding Youth Science Foundation
2010	China Youth Science and Technology Award
2012	China Young Woman Scientist Fellowship

Research Description

The long-term mission of our group is to find better treatment for childhood neuropsychiatric disorders, starting with autism and its co-morbid disorders such as epilepsy. Our scientific pursuit is driven by our profound interest in human behavior and emotions and strong urge to ease children’s suffering. In the next five years we plan to study the genetic basis of autism and the pharmacogenetic profiles of epilepsy drugs. We are building a world-class patient sample biobank for childhood neuropsychiatric disorders, including case-control samples, multiplex families and twins. We aim to bridge neuropsychiatric phenotypes and genotypes at whole new levels by (1) detailed phenotyping of patients to find extreme subtypes or new diseases, (2) capitalizing on the unprecedented opportunities to sequence individual human whole genomes using the next-generation sequencing technologies, and (3) combining top-down, holistic thinking with advanced bioinformatic technologies. To facilitate discoveries in the years to come, our “wet” lab is supported by our “dry” lab that seamlessly integrates electronic patient information, automated sample tracking, individual genome sequences, and bioinformatic analysis pipelines, using MySQL relational database as the foundation and the human reference genome as the scaffold.

Select Publications

1.  Zhou WZ, Ye AY, Sun Z, Tian HH, Pu TZ, Wu YY, Wang DD, Zhao M, Lu SJ, Yang CH, Wei L., Statistical analysis of twenty years (1993-2012) of data from mainland China’s first intervention center for children with Autism Spectrum Disorder. Molecular Autism. 2014, 5:52.

2.  Zhao HQ, Zhang P, Gao H, He X, Dou Y, Huang AY, Liu X, Ye AY, Dong MQ, Wei L. Profiling the RNA editomes of wild-type C. elegans and ADAR mutants. Genome Res. 2014 Nov 4. pii: gr.176107.114. [Epub ahead of print]

3.  Iossifov I, et al, The contribution of de novo coding mutations to autism spectrum disorder, Nature. 2014 Nov 13;515(7526):216-21. doi: 10.1038/nature13908. Epub 2014 Oct 29.

4.  Ding Y, et al, Wei L. "Bioinformatics: Introduction and Methods", a bilingual Massive Open Online Course (MOOC) as a new example for global bioinformatics education. PLoS Computational Biology, 2014, in press

5.  Dong S, Walker MF, Carriero NJ, DiCola M, Willsey AJ, Ye AY, Waqar Z, Gonzalez LE, Overton JD, Frahm S, Keaney JF 3rd, Teran NA, Dea J, Mandell JD, Hus Bal V, Sullivan CA, DiLullo NM, Khalil RO, Gockley J, Yuksel Z, Sertel SM, Ercan-Sencicek AG, Gupta AR, Mane SM, Sheldon M, Brooks AI, Roeder K, Devlin B, State MW, Wei L, Sanders SJ.. De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder. Cell Rep. 2014 Oct 9;9(1):16-23. doi: 10.1016/j.celrep.2014.08.068. Epub 2014 Oct 2.

6.  Huang YA, Xu X, Ye AY, Wu Q, Yan L, Zhao B, Yang X, He Y, Wang S, Zhang Z, Gu B, Zhao HQ, Wang M, Gao H, Gao G, Zhang Z, Yang X, Wu X, Zhang Y, Wei L. Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals. Cell Res. 2014 Nov;24(11):1311-27. doi: 10.1038/cr.2014.131. Epub 2014 Oct 14.

7.  Yang X, Gao H, Zhang J, Xu X, Liu X, Wu X, Wei L, Zhang Y. ATP1A3 Mutations and Genotype-Phenotype Correlation of Alternating Hemiplegia of Childhood in Chinese Patients.  PLoS One. 2014 May 19;9(5):e97274

8.  Gao G, Vibranovski MD, Zhang L, Li Z, Liu M, Zhang YE, Li X, Zhang W, Fan Q, VanKuren NW, Long M, Wei L. A long term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster. Genome Res. 2014. Apr;24(4):629-38.

9.  Willsey AJ, et.al., Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism.  Cell. 2013 Nov 21;155(5):997-1007. doi: 10.1016/j.cell.2013.10.020.

10. Huang Y, Xie C, Ye AY, Li CY, Gao G, Wei L. Recent adaptive events in human brain revealed by meta-analysis of positively selected genes.  PLoS One. 2013 Apr 9;8(4):e61280.

11. Xie C, Zhang YE, Chen JY, Liu CJ, Zhou WZ, Li Y, Zhang M, Zhang R, Wei L, and Li CY. Hominoid-specific de novo protein-coding genes originating from long non-coding RNAs.  PLoS Genet. 2012 Sep;8(9):e1002942.

12. Xu LM, Li JR, Huang Y, Zhao M, Tang X, Wei L. AutismKB: an evidence-based knowledgebase of autism genetics. Nucleic Acids Res. 2012 Jan;40(Database issue):D1016-22

13. Li CY, Zhang Y, Wang Z, Zhang Y, Cao C, Zhang PW, Lu SJ, Li XM, Yu Q, Zheng X, Du Q, Uhl GR, Liu QR, Wei L. A human-specific de novo protein-coding gene associated with human brain functions. PLoS Comput Biol. 2010 Mar 26;6(3):e1000734.

14. Zhang Y, Lu S, Zhao S, Zheng X, Long M, Wei L. Positive selection for the male functionality of a co-retroposed gene in the hominoids, BMC Evolutionary Biology. 2009. 9, 252

15. Gao G, Li JT, Kong L, Tao L, Wei L, Human herpesvirus miRNAs statistically preferentially target host genes involved in cell signaling and adhesion/junction pathways. Cell Research. 2009 May;19(5):665-7

16. Li JT, Zhang Y, Kong L, Liu QR, Wei L., Trans-natural antisense transcripts including noncoding RNAs in 10 species: implications for expression regulation. Nucleic Acids Res. 2008 Sep;36(15):4833-44

17. Li CY, Mao X, Wei L, Genes and (Common) Pathways Underlying Drug Addiction, Plos Computational Biology, 2008, Jan 4;4(1):e2. (This work was featured by Science Signaling, the Economist, Reuters, and ~100 other scientific and public media.)

18. Kong L, Zhang Y, Ye ZQ, Liu XQ, Zhao SQ, Wei L, Gao G. CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine. Nucleic Acids Res. 2007 Jul 1;35:W345-9.

19. Ye ZQ, Zhao SQ, Gao G, Liu XQ, Langlois RE, Lu H, Wei L. Finding new structural and sequence attributes to predict possible disease association of single amino acid polymorphism (SAP). Bioinformatics. 2007 Jun 15;23(12):1444-50.

20. Li CY, Yu Q, Ye ZQ, Sun Y, He Q, Li XM, Zhang W, Luo J, Gu X, Zheng X, Wei L. A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. Cell Res. 2007 Apr;17(4):357-62. (Cover story and featured by a Research Highlight. Highlighted by FDA annual Pediatric Safety Update for Tamiflu.)

21. Cai Z, Mao X, Li S, Wei L. Genome comparison using Gene Ontology (GO) with statistical testing, BMC Bioinformatics 2006, 7:374.

22. Shi YH, Zhu SW, Feng JX, Mao X, Zhang L, Cheng J, Wei L, Wang ZY, Zhu YX, “Transcriptome Profiling, Molecular Biological and Physiological Studies Revealed a Major Role of Ethylene in Cotton Fiber Cell Elongation”,Plant Cell, 2006 Mar;18(3):651-64.

23. Mao X., Cai T., Olyarchuk J.G., Wei L., “Automated Genome Annotation and Pathway Identification Using the KEGG Orthology (KO) As a Controlled Vocabulary”, Bioinformatics, 21(19): 3787–93, 2005

Invited Reviews

1. Wei L, Yu J. Bioinformatics in china: a personal perspective. PLoS Comput Biol. 2008 Apr 25;4(4):e1000020

2. Wei L, Liu Y, Dubchak I, Shon JCY, and Park JY, “Comparative Genomics Approaches to Study Organism Similarities and Differences.” Journal of Biomedical Informatics, 35:142-150, 2002.

Patent

Wei L, Li CY, Ye ZQ, He QY, Yu Q, Zhang WX, Sun Y, Luo J, Gu XC, Zheng XF, Chinese patent “A method to predict the safety of administering Oseltamivir Phosphate”. Patent Number: ZL 200610011569.3. Priority Date: March 28, 2006. Issued: March 26, 2008.