Information
Qi Li,Ph.D.
Director of Genetic Screening Center, NIBS, Beijing, China
Phone：010-80726688-8677
E-mail:wangyibing@nibs.ac.cn

Education:
09/2004-07/2008: Bachelor of Biotechnology, College of Life Science, Shandong Teachers' University

09/2008-07/2011: M.S, Department of Cell Biology, School of Life Science, Peking University

09/2011-07/2016: Ph.D, Department of Physiology, School of Life Science, Peking University

Professional Experience:

08/2016-10/2017: Postdoc, Department of Physiology, School of Life Science, Peking University

11/2017-2021: Postdoc, National Institute of Biological Science

2021-present:Director of Genetic Screening Center, National Institute of Biological Science, Beijing

FunctionGenetic Screening Center:
Adeno-associated

The mission of the Genetic Screening Center (GSC) at the National Institute of Biological Sciences (NIBS) is to support research laboratories in conducting genetic screens using adeno-associated virus (AAV) as a delivery tool. Notably, the GSC collaborates with Professor Qinghua Liu on large-scale sleep screens and provides AAV technology support to other laboratories.

The GSC offers a range of AAV-related technical services, including vector design and construction, AAV packaging, purification, titration, and functional testing, to all labs at NIBS. We currently provide over 20 different capsid variants of recombinant AAVs (rAAVs), which enable efficient transduction of the liver, lung, dermis, muscle, central and peripheral nervous systems, as well as a broad spectrum of other tissues and organs.

      rAAV-mediated genetic delivery—whether for overexpression or knockout of target genes in vivo, ex vivo, or in vitro—has become a powerful and widely adopted approach in everyday biological research and currently serves as a leading platform for clinical trials. To further enhance the efficiency and specificity of rAAVs, the GSC is committed to developing and evolving novel capsid variants through directed evolution, tailored to the demands and interests of different research laboratories.

Publications:

Sleep related publications:

1. Guo, Z., Z. Liu, X. Min, K. Ding, W. Zhang, Z. Jiang, S. Chen, F. Wang, K. He, Q. Li# and Q. Liu#.
A causal link between synaptic transmission and sleep amount regulation in mice. In revision.
2. Zhou, S., B. Shi, L. Chen, X. Yin, M. Liu, C. Wu, H. Wang, X. Wang, B. Li, F. Wang, Q. Li# and Q. Liu# (2025). PP2Acalpha regulates sleep amount and sleep homeostasis in mice. Communications Biology 8(1): 1018.
3. Liu, Z., Z. Guo, J. Xu, R. Zhou, B. Shi, L. Chen, C. Wu, H. Wang, X. Wang, F. Wang, Q. Li# and Q. Liu# (2025). Regulation of Sleep Amount by CRTC1 via Transcription of Crh in Mice. Journal of Neuroscience 45(5):e0786242024.
4. Zhou, R.*, G. Wang*, Q. Li, F. Meng, C. Liu, R. Gan, D. Ju, M. Liao, J. Xu, D. Sang, X. Gao, S. Zhou, K. Wu, Q. Sun, Y. Guo, C. Wu, Z. Chen, L. Chen, B. Shi, H. Wang, X. Wang, H. Li, T. Cai, B. Li, F. Wang, H. Funato, M. Yanagisawa, E. E. Zhang and Q. Liu (2022). A signalling pathway for transcriptional regulation of sleep amount in mice. Nature 612(7940): 519-527.
5. Wang, G.*, Q. Li*, J. Xu, S. Zhao, R. Zhou, Z. Chen, W. Jiang, X. Gao, S. Zhou, Z. Chen, Q. Sun, C. Ma, L. Chen, B. Shi, Y. Guo, H. Wang, X. Wang, H. Li, T. Cai, Y. Wang, Z. Chen, F. Wang and Q. Liu (2022). Somatic genetics analysis of sleep in adult mice. Journal of Neuroscience 42(28): 5617-5640.
6. Deng, B.*, Q. Li*, X. Liu*, Y. Cao*, B. Li, Y. Qian, R. Xu, R. Mao, E. Zhou, W. Zhang, J. Huang and Y. Rao (2019). Chemoconnectomics: Mapping Chemical Transmission in Drosophila. Neuron 101(5): 876-893 e874.
7. Yin, X., Z. Zhang, R. Zhou, P. Zuo, D. Sang, S. Zhou, B. Shi, L. Chen, C. Wu, Y. Guo, F. Wang, E. E. Zhang, Q. Li, M. Yanagisawa and Q. Liu (2025). Calcineurin governs baseline and homeostatic regulations of non-rapid eye movement sleep in mice. PNAS 122, e2418317122.
8. Zhou, R., C. Zhang, R. Gan, X. Yin, M. Wang, B. Shi, L. Chen, C. Wu, Q. Li and Q. Liu (2025). Transcriptional regulation of daily sleep amount by TCF4-HDAC4-CREB complex in mice. Sleep 48(5).
9. Zhao, H., M. Liao, R. Huo, T. He, H. Tian, Z. Li, C. Chen, Z. Yu, J. Chai, X. Song, R. Shao, S. Ying, W. Gao, L. Liu, D. Sang, Q. Li, H. Li, F. Wang, D. Ju and E. E. Zhang (2026). "Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice." Cell 189:1-17.
10. Sang, D., K. Lin, Y. Yang, G. Ran, B. Li, C. Chen, Q. Li, Y. Ma, L. Lu, X. Y. Cui, Z. Liu, S. Q. Lv, M. Luo, Q. Liu, Y. Li and E. E. Zhang (2023). Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals. Cell 186(25): 5500-5516 e5521.
11. Liao, M., X. Gao, C. Chen, Q. Li, Q. Guo, H. Huang, E. Zhang and D. Ju (2023). Integrated neural tracing and in-situ barcoded sequencing reveals the logic of SCN efferent circuits in regulating circadian behaviors. Science China Life Sciences:1869-1889.
Other collaborated publications:
12. Chen, D., Z. Yu, W. Wu, Y. Du, Q. Du, H. Huang, Y. Li, T. Xuan, Y. Liang, Y. Liu, Z. Wang, R. Su, Y. Zhao, Q. Li, M. Luo, F. Wang, J. Li, C. Chuong, Z. Lin, T. Chen (2025). Fibroblast bioelectric signaling drives hair growth. Cell 188, 1-19
13. Sun, Y., Y. Cao, H. Wan, A. Memetimin, Y. Cao, L. Li, C. Wu, M. Wang, S. Chen, Q. Li, Y. Ma, M. Dong and H. Jiang (2024). A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass. Molecular Cell 84(2): 327-344 e329.
14. Cao, Y., J. Zheng, H. Wan, Y. Sun, S. Fu, S. Liu, B. He, G. Cai, Y. Cao, H. Huang, Q. Li, Y. Ma, S. Chen, F. Wang and H. Jiang (2023). A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease. EMBO Journal 42(13): e113033.
15. He, B., H. Yu, S. Liu, H. Wan, S. Fu, S. Liu, J. Yang, Z. Zhang, H. Huang, Q. Li, F. Wang, Z. Jiang, Q. Liu and H. Jiang (2022). Mitochondrial cristae architecture protects against mtDNA release and inflammation. Cell Report 41(10): 111774.
16. Petruccelli, E., Q. Li, Y. Rao and T. Kitamoto (2016). The Unique Dopamine/Ecdysteroid Receptor Modulates Ethanol-Induced Sedation in Drosophila. Journal of Neuroscience 36(16): 4647-4657.
17. Song, S., Y. Yuan, J. Lu, Q. Li, Z. Zhu, Q. Fan, Y. Xue, Z. C. Lai and W. Zhang (2013). The Drosophila ortholog of breast cancer metastasis suppressor gene, dBrms1, is critical for developmental timing through regulating ecdysone signaling. Developemtal Biology 380(2): 344-350.