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科学研究

2015

Original Research Articles

  1. Zhu, Xing & Ye, Keqiong*. Cmr4 is the slicer in the RNA-targeting Cmr CRISPR complex. Nucleic Acids Res 43, 1257-1267, doi:10.1093/nar/gku1355 (2015).


  2. Zhu, Ming, Wu, Gang, Li, Yu-Xin, Stevens, Julia Kathrin, Fan, Chao-Xuan, Spang, Anne & Dong, Meng-Qiu*. Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans. PLoS One 10, e0130778, doi:10.1371/journal.pone.0130778 (2015).


  3. Zhou, Yu & Huang, Niu*. Binding site druggability assessment in fragment-based drug design. Methods Mol Biol 1289, 13-21, doi:10.1007/978-1-4939-2486-8_2 (2015).


  4. Zhou, Jingfeng, Jia, Chunying, Feng, Qiru, Bao, Junhong & Luo, Minmin*. Prospective coding of dorsal raphe reward signals by the orbitofrontal cortex. J Neurosci 35, 2717-2730, doi:10.1523/JNEUROSCI.4017-14.2015 (2015).


  5. Zhao, Yue & Shao, Feng*. The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus. Immunol Rev 265, 85-102, doi:10.1111/imr.12293 (2015).


  6. Zhao, Han-Qing, Zhang, Pan, Gao, Hua, He, Xiandong, Dou, Yanmei, Huang, August Y, Liu, Xi-Ming, Ye, Adam Y, Dong, Meng-Qiu* & Wei, Liping*. Profiling the RNA editomes of wild-type C. elegans and ADAR mutants. Genome Res 25, 66-75, doi:10.1101/gr.176107.114 (2015).


  7. Zhao, H. Q., Zhang, P., Gao, H., He, X., Dou, Y., Huang, A. Y., Liu, X. M., Ye, A. Y., Dong, M. Q. & Wei, L. Profiling the RNA editomes of wild-type C. elegans and ADAR mutants. Genome Res 25, 66-75, doi:10.1101/gr.176107.114 (2015).


  8. Zhang, Hongjuan, Cao, Jing, Li, Lin, Liu, Yanbin, Zhao, Hong, Li, Nan, Li, Bo, Zhang, Aiqun, Huang, Huanwei, Chen, She, Dong, Mengqiu, Yu, Lei, Zhang, Jian & Chen, Liang*. Identification of urine protein biomarkers with the potential for early detection of lung cancer. Sci Rep 5, 11805, doi:10.1038/srep11805 (2015).


  9. Yang, Jieling, Zhao, Yue & Shao, Feng*. Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity. Curr Opin Immunol 32, 78-83, doi:10.1016/j.coi.2015.01.007 (2015).


  10. Yang, Fu, Zhao, Rui, Fang, Xiaofeng, Huang, Huanwei, Xuan, Yang, Ma, Yanting, Chen, Hongyan, Cai, Tao, Qi, Yijun & Xi, Rongwen*. The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline. EMBO Rep 16, 965-974, doi:10.15252/embr.201540084 (2015).


  11. Yan, Huan, Liu, Yang, Sui, Jianhua & Li, Wenhui*. NTCP opens the door for hepatitis B virus infection. Antiviral Res 121, 24-30, doi:10.1016/j.antiviral.2015.06.002 (2015).


  12. Yan, Huan & Li, Wenhui*. Sodium taurocholate cotransporting polypeptide acts as a receptor for hepatitis B and D virus. Dig Dis 33, 388-396, doi:10.1159/000371692 (2015).


  13. Xu, Zijian, Wang, Wenjie, Jiang, Kaiju, Yu, Zhou, Huang, Huanwei, Wang, Fengchao, Zhou, Bin & Chen, Ting*. Embryonic attenuated Wnt/beta-catenin signaling defines niche location and long-term stem cell fate in hair follicle. Elife 4, e10567, doi:10.7554/eLife.10567 (2015).


  14. Xu, Ying, An, Futing, Borycz, Jolanta A, Borycz, Janusz, Meinertzhagen, Ian A & Wang, Tao*. Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors. PLoS Genet 11, e1005764, doi:10.1371/journal.pgen.1005764 (2015).


  15. Xu, Xiaojing, Yang, Xiaoxu, Wu, Qixi, Liu, Aijie, Yang, Xiaoling, Ye, Adam Yongxin, Huang, August Yue, Li, Jiarui, Wang, Meng, Yu, Zhe, Wang, Sheng, Zhang, Zhichao, Wu, Xiru, Wei, Liping* & Zhang, Yuehua*. Amplicon Resequencing Identified Parental Mosaicism for Approximately 10% of "de novo" SCN1A Mutations in Children with Dravet Syndrome. Hum Mutat 36, 861-872, doi:10.1002/humu.22819 (2015).


  16. Wu, Hong#, Wang, Aoli#, Zhang, Wei3, Wang, Beilei#, Chen, Cheng, Wang, Wenchao, Hu, Chen, Ye, Zi, Zhao, Zheng, Wang, Li, Li, Xixiang, Yu, Kailin, Liu, Juan, Wu, Jiaxin, Yan, Xiao-E, Zhao, Peng, Wang, Jinhua, Wang, Chu, Weisberg, Ellen L, Gray, Nathanael S, Yun, Cai-Hong, Liu, Jing*, Chen, Liang* & Liu, Qingsong*. Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells. Oncotarget 6, 31313-31322, doi:10.18632/oncotarget.5182 (2015).


  17. Wang, Zhijie, Shen, Zhirong, Li, Zhenxiang, Duan, Jianchun, Fu, Shuai, Liu, Zhentao, Bai, Hua, Zhang, Zemin, Zhao, Jun, Wang, Xiaodong* & Wang, Jie*. Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations. Proc Natl Acad Sci U S A 112, 9990-9995, doi:10.1073/pnas.1510837112 (2015).


  18. Wang, Y & Wang, Xiaodong*. Entosis and Related Forms of Cell Death within Cells. Curr Mol Med 15, 805-809, doi:10.2174/1566524015666151026100339 (2015).


  19. Wang, Daqing, He, Xiaobing, Zhao, Zhe, Feng, Qiru, Lin, Rui, Sun, Yue, Ding, Ting, Xu, Fuqiang*, Luo, Minmin* & Zhan, Cheng*. Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons. Front Neuroanat 9, 40, doi:10.3389/fnana.2015.00040 (2015).


  20. Wang, Chenhui & Xi, Rongwen*. Keeping intestinal stem cell differentiation on the Tramtrack. Fly (Austin) 9, 110-114, doi:10.1080/19336934.2015.1119947 (2015).


  21. Wang, Chenhui, Guo, Xingting, Dou, Kun, Chen, Hongyan & Xi, Rongwen*. Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages. Development 142, 3321-3331, doi:10.1242/dev.123208 (2015).


  22. Shi, Jianjin, Zhao, Yue, Wang, Kun, Shi, Xuyan, Wang, Yue, Huang, Huanwei, Zhuang, Yinghua, Cai, Tao, Wang, Fengchao & Shao, Feng*. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526, 660-665, doi:10.1038/nature15514 (2015).


  23. Ning, Yong-Qiang, Ma, Ze-Yang, Huang, Huan-Wei, Mo, Huixian, Zhao, Ting-ting, Li, Lin, Cai, Tao, Chen, She, Ma, Ligeng & He, Xin-Jian*. Two novel NAC transcription factors regulate gene expression and flowering time by associating with the histone demethylase JMJ14. Nucleic Acids Res 43, 1469-1484, doi:10.1093/nar/gku1382 (2015).


  24. Meng, Lingjun, Jin, Wei & Wang, Xiaodong*. RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality. Proc Natl Acad Sci U S A 112, 11007-11012, doi:10.1073/pnas.1514730112 (2015).


  25. Luo, Minmin*, Zhou, Jingfeng & Liu, Zhixiang. Reward processing by the dorsal raphe nucleus: 5-HT and beyond. Learn Mem 22, 452-460, doi:10.1101/lm.037317.114 (2015).


  26. Lu, Shichao*, Gong, Yaling & Zhou, Demin. Transition Metal-Free Oxidative Radical Decarboxylation/Cyclization for the Construction of 6-Alkyl/Aryl Phenanthridines. J Org Chem 80, 9336-9341, doi:10.1021/acs.joc.5b01518 (2015).


  27. Lu, Shan, Fan, Sheng-Bo, Yang, Bing, Li, Yu-Xin, Meng, Jia-Ming, Wu, Long, Li, Pin, Zhang, Kun, Zhang, Mei-Jun, Fu, Yan, Luo, Jincai, Sun, Rui-Xiang, He, Si-Min* & Dong, Meng-Qiu*. Mapping native disulfide bonds at a proteome scale. Nat Methods 12, 329-331, doi:10.1038/nmeth.3283 (2015).


  28. Lu, Qiuhe, Xu, Yue, Yao, Qing, Niu, Miao & Shao, Feng*. A polar-localized iron-binding protein determines the polar targeting of Burkholderia BimA autotransporter and actin tail formation. Cell Microbiol 17, 408-424, doi:10.1111/cmi.12376 (2015).


  29. Lu, Qiuhe, Li, Shan & Shao, Feng*. Sweet Talk: Protein Glycosylation in Bacterial Interaction With the Host. Trends Microbiol 23, 630-641, doi:10.1016/j.tim.2015.07.003 (2015).


  30. Liu, Xiao-Man, Sun, Ling-Ling, Hu, Wen, Ding, Yue-He, Dong, Meng-Qiu & Du, Li-Lin*. ESCRTs Cooperate with a Selective Autophagy Receptor to Mediate Vacuolar Targeting of Soluble Cargos. Mol Cell 59, 1035-1042, doi:10.1016/j.molcel.2015.07.034 (2015).


  31. Liu, Xiao-Man & Du, Li-Lin*. A selective autophagy pathway takes an unconventional route. Autophagy 11, 2381-2382, doi:10.1080/15548627.2015.1110669 (2015).


  32. Liu, X. M. & Du, L. L. A selective autophagy pathway takes an unconventional route. Autophagy 11, 2381-2382, doi:10.1080/15548627.2015.1110669 (2015).


  33. Liu, Nan, Zhang, Zhuqiang, Wu, Hui*, Jiang, Yonghua, Meng, Lingjun, Xiong, Jun, Zhao, Zuodong, Zhou, Xiaohua, Li, Jia, Li, Hong, Zheng, Yong, Chen, She, Cai, Tao, Gao, Shaorong & Zhu, Bing*. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes Dev 29, 379-393, doi:10.1101/gad.254425.114 (2015).


  34. Li, Wenhui*. The hepatitis B virus receptor. Annu Rev Cell Dev Biol 31, 125-147, doi:10.1146/annurev-cellbio-100814-125241 (2015).


  35. Li, Tie-Mei, Liu, Weilong, Lu, Shan, Zhang, Yan-Ping, Jia, Le-Mei, Chen, Jie, Li, Xiangke, Lei, Xiaoguang & Dong, Meng-Qiu*. No Significant Increase in the Delta4- and Delta7-Dafachronic Acid Concentration in the Long-Lived glp-1 Mutant, nor in the Mutants Defective in Dauer Formation. G3 (Bethesda) 5, 1473-1479, doi:10.1534/g3.115.018812 (2015).


  36. Li, Dianrong, Xu, Tao, Cao, Yang, Wang, Huayi, Li, Lin, Chen, She, Wang, Xiaodong* & Shen, Zhirong*. A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis. Proc Natl Acad Sci U S A 112, 5017-5022, doi:10.1073/pnas.1505244112 (2015).


  37. Kuo, Ying, Huang, Huanwei, Cai, Tao & Wang, Tao*. Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila. Sci Rep 5, 10339, doi:10.1038/srep10339 (2015).


  38. Kang, Lan & Gao, Shaorong*. Generation of Viable Mice from Induced Pluripotent Stem Cells (iPSCs) Through Tetraploid Complementation. Methods Mol Biol 1330, 125-132, doi:10.1007/978-1-4939-2848-4_12 (2015).


  39. Huang, Yu#, Xie, Jun# & Wang, Tao*. A Fluorescence-Based Genetic Screen to Study Retinal Degeneration in Drosophila. PLoS One 10, e0144925, doi:10.1371/journal.pone.0144925 (2015).


  40. Huang, Xingchuan, Dong, Wenjuan, Milewska, Aleksandra, Golda, Anna, Qi, Yonghe, Zhu, Quan K, Marasco, Wayne A, Baric, Ralph S, Sims, Amy C, Pyrc, Krzysztof, Li, Wenhui* & Sui, Jianhua*. Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme. J Virol 89, 7202-7213, doi:10.1128/JVI.00854-15 (2015).


  41. Hu, Zexi, Wan, Xiaobo, Hao, Rui, Zhang, Heng, Li, Li, Li, Lin, Xie, Qiang, Wang, Peng, Gao, Yibo, Chen, She, Wei, Min, Luan, Zhidong, Zhang, Aiqun, Huang, Niu & Chen, Liang*. Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity. PLoS One 10, e0123623, doi:10.1371/journal.pone.0123623 (2015).


  42. Hu, Zexi#, Hu, Yong#, Liu, Xicheng, Xi, Rongwen, Zhang, Aiqun, Liu, Deruo, Xie, Qiang & Chen, Liang*. Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor. Oncotarget 6, 31628-31639, doi:10.18632/oncotarget.5221 (2015).


  43. Hu, Wen, Suo, Fang & Du, Li-Lin*. Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast. Genome Biol Evol 7, 3496-3510, doi:10.1093/gbe/evv238 (2015).


  44. Hong, Benke, Li, Houhua, Wu, Jinbao, Zhang, Jing & Lei, Xiaoguang*. Total syntheses of (-)-huperzine Q and (+)-lycopladines B and C. Angew Chem Int Ed Engl 54, 1011-1015, doi:10.1002/anie.201409503 (2015).


  45. Hong, Benke, Li, Chao, Wang, Zhen, Chen, Jie, Li, Houhua* & Lei, Xiaoguang*. Enantioselective Total Synthesis of (-)-Incarviatone A. J Am Chem Soc 137, 11946-11949, doi:10.1021/jacs.5b08551 (2015).


  46. He, Wenhui*, Ren, Bijie*, Mao, Fengfeng, Jing, Zhiyi, Li, Yunfei, Liu, Yang, Peng, Bo, Yan, Huan, Qi, Yonghe, Sun, Yinyan, Guo, Ju-Tao, Sui, Jianhua, Wang, Fengchao & Li, Wenhui*. Hepatitis D Virus Infection of Mice Expressing Human Sodium Taurocholate Co-transporting Polypeptide. PLoS Pathog 11, e1004840, doi:10.1371/journal.ppat.1004840 (2015).


  47. Han, Yong-Feng, Huang, Huan-Wei, Li, Lin, Cai, Tao, Chen, She & He, Xin-Jian*. The Cytosolic Iron-Sulfur Cluster Assembly Protein MMS19 Regulates Transcriptional Gene Silencing, DNA Repair, and Flowering Time in Arabidopsis. PLoS One 10, e0129137, doi:10.1371/journal.pone.0129137 (2015).


  48. Guo, Qingchun, Zhou, Jingfeng, Feng, Qiru, Lin, Rui, Gong, Hui, Luo, Qingming, Zeng, Shaoqun, Luo, Minmin* & Fu, Ling*. Multi-channel fiber photometry for population neuronal activity recording. Biomed Opt Express 6, 3919-3931, doi:10.1364/BOE.6.003919 (2015).


  49. Guo, Qingchun, Wang, Daqing, He, Xiaobin, Feng, Qiru, Lin, Rui, Xu, Fuqiang, Fu, Ling & Luo, Minmin*. Whole-brain mapping of inputs to projection neurons and cholinergic interneurons in the dorsal striatum. PLoS One 10, e0123381, doi:10.1371/journal.pone.0123381 (2015).


  50. Gong, Zhou#, Ding, Yue-He#, Dong, Xu, Liu, Na, Zhang, E Erquan, Dong, Meng-Qiu* & Tang, Chun*. Visualizing the Ensemble Structures of Protein Complexes Using Chemical Cross-Linking Coupled with Mass Spectrometry. Biophys Rep 1, 127-138, doi:10.1007/s41048-015-0015-y (2015).


  51. Gao, Shuai, Zheng, Caihong, Chang, Gang, Liu, Wenqiang, Kou, Xiaochen, Tan, Kun, Tao, Li, Xu, Kai, Wang, Hong, Cai, Jun*, Tian, Jianhui* & Gao, Shaorong*. Unique features of mutations revealed by sequentially reprogrammed induced pluripotent stem cells. Nat Commun 6, 6318, doi:10.1038/ncomms7318 (2015).


  52. Gao, Lei, Jiang, Yonghua, Mu, Libing, Liu, Yanbin, Wang, Fengchao, Wang, Peng, Zhang, Aiqun, Tang, Nan, Chen, Ting, Luo, Minmin, Yu, Lei, Gao, Shaorong & Chen, Liang*. Efficient Generation of Mice with Consistent Transgene Expression by FEEST. Sci Rep 5, 16284, doi:10.1038/srep16284 (2015).


  53. Fan, Sheng-Bo, Meng, Jia-Ming, Lu, Shan, Zhang, Kun, Yang, Hao, Chi, Hao, Sun, Rui-Xiang, Dong, Meng-Qiu* & He, Si-Min. Using pLink to Analyze Cross-Linked Peptides. Curr Protoc Bioinformatics 49, 8 21 21-28 21 19, doi:10.1002/0471250953.bi0821s49 (2015).


  54. Du, Jin-Lu, Zhang, Su-Wei, Huang, Huan-Wei, Cai, Tao, Li, Lin, Chen, She & He, Xin-Jian*. The Splicing Factor PRP31 Is Involved in Transcriptional Gene Silencing and Stress Response in Arabidopsis. Mol Plant 8, 1053-1068, doi:10.1016/j.molp.2015.02.003 (2015).


  55. Dong, Ting, Liao, Daohong, Liu, Xiaohui & Lei, Xiaoguang*. Using Small Molecules to Dissect Non-apoptotic Programmed Cell Death: Necroptosis, Ferroptosis, and Pyroptosis. Chembiochem 16, 2557-2561, doi:10.1002/cbic.201500422 (2015).


  56. Dong, Ting, Li, Chao, Wang, Xing, Dian, Longyang, Zhang, Xiuguo, Li, Lin, Chen, She, Cao, Ran, Li, Li, Huang, Niu, He, Sudan* & Lei, Xiaoguang*. Ainsliadimer A selectively inhibits IKKalpha/beta by covalently binding a conserved cysteine. Nat Commun 6, 6522, doi:10.1038/ncomms7522 (2015).


  57. Cheng, Shiya, Wang, Kun, Zou, Wei, Miao, Rui, Huang, Yaling, Wang, Haibin & Wang, Xiaochen*. PtdIns(4,5)P(2) and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance. J Cell Biol 210, 485-502, doi:10.1083/jcb.201501038 (2015).


  58. Cao, Ran, Wang, Yanli & Huang, Niu*. Discovery of 2-Acylaminothiophene-3-Carboxamides as Multitarget Inhibitors for BCR-ABL Kinase and Microtubules. J Chem Inf Model 55, 2435-2442, doi:10.1021/acs.jcim.5b00540 (2015).



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