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学术报告

12:30-13:30, Friday, February 23, 2018

Speaker: Qing Li, Ph.D.

Associate Professor

Peking University

Topic: New Insights to Chromatin Replication

Host: Ting Chen, Ph.D.

Abstract

One of the central questions in biology is how epigenetic states defined by chromatin organization are transmitted into daughter cells during mitotic cell division. The “initial” step for epigenetic inheritance occurs during the S phase of the cell cycle, while the entire genome accurately replicated, the chromatin landscape has to be reproduced on newly synthesized DNA to restore epigenetic states. Accumulating evidence is suggesting that these intertwined biological processes are fundamental for normal development, and further, exert profound influences on human health. Our research aims to dissect the mechanisms of chromatin replication, to determine its role during epigenetic inheritance, and to explore the connections among epigenetic inheritance, genome stability, and cell fate determination. Specifically, using both yeast and mammalian cells, we have focused on determining how nucleosomes, the basic repeating units of chromatin, are assembled in a process coupled to DNA replication. In this talk, I will introduce our recent progress on how multiple histone chaperones connect to replisome components during replication-coupled nucleosome assembly and will report a previously-undocumented mechanism through which RPA is loaded at replication forks.