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实验室

10:00-11:00, Monday, September 16, 2019


Speaker:Takeshi Sakurai, Ph.D.

Professor,

International Institute for Integrative Sleep Medicine,

University of Tsukuba

Topic: Induction of Hibernation-like State in Mice: A Novel Neuronal Circuit of Regulated Hypometabolism

Host:  Qinghua Liu, Ph.D.

Abstract

Some mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity, a state known as hibernation. Hibernating animals fully recover to a normal condition with no organ or tissue damage. Because a hypometabolic state could be beneficial for many medical applications, this ability has evoked great interest. Here, we found that excitatory manipulation of neurons that are identified by expression of particular genetic marker in the anteroventricular periventricular hypothalamus induced a long-lasting hypothermic state similar to hibernation. In this state, the theoretical set-point of body temperature of mice was significantly lowered, but their behavior and metabolism were still actively regulated, showing stark contrast to states induced by anesthesia. This finding opens the door to the development of methods to induce a hibernation-like state in non-hibernating mammalian species including humans.