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实验室

16:00-17:00, Tuesday, May 21, 2019


Speaker: Yanzhuang Wang, Ph.D.

Professor

Department of Molecular, Cellular and Developmental Biology

University of Michigan

Topic: Golgi Structure Formation, Function, and Stress Response

Host: Li-Lin Du, Ph.D.

Abstract

The Golgi is an essential cellular membrane organelle with a unique stacked structure and broad functions in protein and lipid trafficking, processing and secretion. Dr. Wang’s research is focused on the molecular mechanisms of Golgi biogenesis, function, and defects in human diseases. Using a unique multidisciplinary approach, he found that the Golgi stacking proteins GRASP65 and GRASP55 hold the Golgi membranes into stacks by forming trans-oligomers. Using GRASPs as tools to manipulate Golgi stack formation, he demonstrated that Golgi stacking slows protein trafficking to ensure accurate glycosylation and sorting. He also discovered that under glucose and nutrient deprivation, the Golgi stacking protein GRASP55 serves as an energy sensor to promote autophagosome maturation. In addition, he found that monoubiquitination regulates post-mitotic Golgi membrane fusion. More recently, he discovered that the Alzheimer-associated amyloid Aβ causes Golgi-fragmentation, leading to increases in toxic amyloid production. More importantly, his study showed that experimental rescue of the Golgi structure could significantly reduce Aβ secretion, pointing to the Golgi as a potential drug target for treating Alzheimer’s disease. His long-term goal is to develop molecular tools to stabilize Golgi structure and function, and ultimately to delay or reverse disease development.