当前位置:首页 / 科学研究 / 实验室 / 正文

实验室

10:30-11:30, Tuesday, December 18, 2018


Speaker:Junmin Peng Ph.D.

Professor, Structural Biology & Developmental Neurobiology

Director, Center for Proteomics and Metabolomics

St. Jude Children's Research Hospital

Memphis, TN, USA

Topic: Omics-based systems biology of Alzheimer’s Disease

Host: Meng-Qiu Dong, Ph.D.

Abstract

Dr. Peng has been interested in developing high-throughput mass spectrometry-based proteomics and metabolomics technologies, systems biology approaches, and the application to biomedical challenges (e.g. ubiquitin biology, Alzheimer’s disease and cancer). To understand the pathogenesis of Alzheimer disease (AD), the most common form of dementia, the Peng group profiled the whole proteome, aggregated proteome, and phosphoproteome in multiple stages of AD, and in other non-AD neurodegenerative disorders, leading to numerous novel disease networks. This comprehensive study identified the accumulation of U1-70K and other U1 snRNP spliceosome components in AD. Multiple U1 snRNP subunits form cytoplasmic tangle-like structures in AD but not in other diseases. RNA-seq reveals dysregulated RNA processing with accumulation of unspliced RNA species in AD. Furthermore, a brain-specific transgenic mouse model has been generated for deregulating the U1-70K activity and recapitulating many AD symptoms. These data demonstrate unique U1 snRNP pathology and abnormal RNA splicing in AD. In addition, the systems biology approaches are also used to identify therapeutic vulnerabilities in pediatric cancers.