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实验室

10:00-11:00, Thursday, November 8, 2018


Speaker: Coleen T. Murphy, Ph.D.

Professor

Department of Molecular Biology

Lewis-Sigler Institute for Integrative Genomics

Princeton University, USA

Topic: Insulin Signaling Regulation of Quality of Life with Age

Host: Mengqiu Dong, Ph.D.

Abstract

“Longevity pathways” couple the timing of reproduction, based on information the organism perceives about its environment and nutrient status, with somatic health; selection for any longevity pathway must act at the level of reproduction. Because my lab and I are interested in reproductive and cognitive decline with age, and how they are regulated both cell autonomously and non-autonomously, the work in my lab incorporates several lines of research that are unified by this reasoning. Understanding how the long-lived and very healthy daf-2 insulin receptor mutant maintains its cognitive function, reproductive ability, and other health markers with age has been instructive in identifying potential pathways to slow aging and maintain important functions with age. In order to better understand these phenotypes, we have developed microfluidic assays to study timing of reproduction during reproductive aging, the strength of the animal’s outer cuticle, and various tests of neuronal behaviors, together with gene expression changes that are regulated in a tissue-specific manner. Together, this information can help explain how long-lived animals are able to carry out functions for an extended time, and may help shed light on how to extend analogous functions in humans.