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实验室

10:00-11:00, Tuesday, September 4, 2018


Speaker: Peter Dayan, Ph.D.

Professor and Director,

Gatsby Charitable Foundation Computational Neuroscience Unit

University College London

Topic: The Long and the Short of Serotonergic Stimulation: Selective Effects on the Learning Rate for Rewards

Host:     Minmin Luo, Ph.D.

Abstract

Serotonin has widespread, but computationally obscure, modulatory effects on learning and cognition. Here, we studied the impact of optogenetic stimulation of dorsal raphe serotonin neurons in mice performing a non-stationary, reward-driven decision-making task.Animals showed two distinct choice strategies. Choices after short inter-trial-intervals (ITIs) depended only on the last trial outcome and followed a win-stay-lose-switch pattern. In contrast, choices after long ITIs reflected outcome history over multiple trials, as described by reinforcement learning models. We found that optogenetic stimulation during a trial significantly boosted the rate of learning that occurred due to the outcome of that trial, but these effects were only exhibited on choices after long ITIs.