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Yi Rao, Ph.D.
Investigator and Associate Director for Academic Affairs, NIBS, Beijing, China
Professor and Dean, Peking University School of Life Sciences
Phone：86-10-80726688-8368
Fax： 86-10-80726673
E-mail：raoyi@nibs.ac.cn
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Education
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1978-1983 |
MB, Jiangxi Medical College, China |
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1983-1985 |
MS Student, Shanghai Medical University |
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1985-1991 |
Ph. D. in Neuroscience, University of California at San Francisco, USA |
Professional Experience
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2007- |
Professor and Dean, Peking University School of Life Sciences |
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2004- |
Investigator and Deputy Director for Academic Affairs, National Institute of Biological Sciences, Beijing, China |
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2006-2007 |
Elsa Swanson Professor of Neurology, Northwestern University Feinberg School of Medicine |
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2006-2007 |
Director of Research，Feinberg Clinical Neuroscience Research Institute, Northwestern University Feinberg School of Medicine |
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2004-2007 |
Professor of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA |
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2004-2006 |
Deputy Director, Northwestern University Institute for Neuroscience |
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1994-2004 |
Department of Anatomy and Neurobiology at Washington University School of Medicine in St. Louis, Missouri, USA |
Professional Service
Editorial Boards
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2001- 2006 |
Journal of Neuroscience |
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2006-present |
Developmental Biology |
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2006-present |
PloS One |
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2000- present |
Neuroscience Research |
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2001- present |
Faculty of 1000 |
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2001-2008 |
NeuroSignals |
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2002- present |
Developmental Brain Research |
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2006-present |
Cell Research |
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2003-2005 |
Chinese Science Bulletin |
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2005- present |
Neuroscience Bulletin |
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1999- present |
The Twenty-First Century |
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2004-present |
Science and Culture Commentary |
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2004-present |
Science and Technology China |
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1998 |
Vice Chair, Gordon Conference on Molecular and Cellular Neurobiology |
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2000 |
Chair, Gordon Conference on Molecular and Cellular Neurobiology |
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2003 |
Organizer, IBRO Symposium on Development and Evolution of Cortical Specification |
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1999-2001 |
Panelist, Developmental Neuroscience Panel, NSF |
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2006- |
Adjunct Professor, University of Science and Technology of China |
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2004- |
Adjunct Investigator, Institute of Biophysics, Chinese Academy of Sciences |
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2002-2005 |
Co-Director, Shanghai Institute for Advanced Study, Chinese Academy of Sciences |
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2002- |
Adjunct Investigator, Institute of the History of Natural Sciences, Chinese Academy |
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1999- |
Member of the Council, Institute of Neuroscience, Chinese Academy of Sciences |
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1999- |
Adjunct Investigator, Institute of Neuroscience, Chinese Academy of Sciences |
Research Description:
We have two major lines of research: the molecular studies of neuronal polarity in mammals and genetic analysis of behavior in Drosophila.
Polarity is a basic cellular feature. Each neuron usually has an axon and multiple dendrites, each of which play different roles: axons usually send signals and dendrites receive them. Abnormalities in neuronal polarity disrupt informational flow in the nervous system. Molecular and subcellular studies of neuronal polarity will contribute to our understanding of the basic mechanisms and may also suggest new approaches to facilitate recovery after neural injuries. Our lab currently focuses on signal transduction pathways involved in establishing and maintaining neuronal polarity.
We use genetic approaches to study behavior in Drosophila. The initial attempts are made to explore the origins of complex behavior in Drosophila and establish Drosophila models of these behavioral paradigms. Once established, these models will make it possible to identify important mutants and their genetic basis. The identification of these genes will allow for further molecular and neuronal network level studies on the specific pathways responsible for behavioral traits in Drosophila.
http://raolab.nibs.ac.cn/
Publications:
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1. |
Zhou C, Rao Yong, and Rao Y (2008). A subset of octopaminergic neurons are important for Drosophila aggression. Nature Neurosci 11:1059-1061. |
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2. |
Li X, Gao X, Liu G, Xiong W, Wu J, Rao Y (2008). Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling. Nature Neurosci 11:28-35 |
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3. |
Guo W, Jiang H, Gray V, Dedhar S, and Rao Y (2007). Role of the integrin-linked kinase (ILK) in determining neuronal polarity. Dev Biol 306:457-468. |
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4. |
Jiang H., Guo W., Liang X.H., and Rao Y.. Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3b and its upstream regulators. Cell. 2005; 120: 123-135. |
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5. |
Liu G., Beggs H., Jürgensen C., Park H.T., Tang H., Gorski J., Jones K.R., Reichardt L.F., Wu J.Y., and Rao Y.. Netrin requires the focal adhesion kinase and the Src family kinases to induce axon outgrowth and to attract axons. Nature Neurosci. 2004; 7: 1222. |
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6. |
Ward M.E., Wu J.Y. and Rao Y.. Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells. Proc Natl Acad Sci USA. 2004; 101:970-974. |
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7. |
Zhu Y., Yu T., Zhang X-C, Nagasawa T., Wu J.Y., and Rao Y.. Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Nat Neurosci. 2002; 5: 719-720. |
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8. |
Wong K., Ren X-R, Huang Y-Z, Xie Y., Liu G., Saito H., Tang H., Wen L., Brady-Kalnay S.M., Mei L., Wu J.Y., Xiong W-C, and Rao Y.. Signal Transduction in Neuronal Migration: Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway. Cell. 2001; 107: 209-221. |
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9. |
Wu J.Y., Feng L., Park H-T, Havlioglu N., Wen L., Tang H., Bacon K.B., Jiang Z., Zhang X-C, and Rao Y.. Slit, a molecule known to guide axon projection and neuronal migration, inhibits leukocyte chemotaxis induced by chemotactic factors. Nature. 2001; 410: 948-952. |
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10. |
Wu W., Wong K., Chen J.H., Jiang Z.H., Dupuis S., Wu J.Y., and Rao Y.. Directional guidance of neuronal migration in the olfactory system by the protein Slit. Nature. 1999; 400: 331-336. |
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11. |
Li H.S., Chen J.H., Wu W., Fagaly T., Yuan W.L., Zhou L., Dupuis S., Jiang Z., Nash W., Gick C., Ornitz D., Wu J.Y., and Rao Y.. Vertebrate Slit, a secreted ligand for the transmembrane protein Roundabout, is a repellent for olfactory bulb axons. Cell. 1999; 96: 807-818. |
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12. |
Li H.S., Tierney C., Wen L., Wu J.Y. and Rao Y.. A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal mesoderm. Development. 1997; 124: 603-615. |
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Rao Y., Jan L.Y., and Jan Y.N.. Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins. Nature. 1990; 345: 163-167. |
Minireview
Jiang H, and Rao Y. (2005). Axon formation: fate versus growth. Nat Neurosci 8:544-6.
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