NIBS 北京生命科学研究所
  News of NIBS
On September 3, 2010, studies toward the total synthesis of complex natural product (+)-ainsliadimer A from Dr. Xiaoguang Lei’s laboratory at National Institute of Biological Sciences, Beijing (NIBS) have been published in Organic Letters, entitled “A Biomimetic Total Synthesis of (+)-Ainsliadimer A”. (http://pubs.acs.org/doi/pdf/10.1021/ol101705j)
Aug. 05, 2010--- Studies from Dr. Feng Shao’s laboratory at National Institute of Biological Sciences, Beijing (NIBS) reveal that pathogenic bacteria can inject effector proteins into host cells to deamidate ubiquitin and ubiquitin-like protein, leading to dysfunction of the host ubiquitination pathway. The work entitled “Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family” is published in the journal Science as early online publication (Science Express).
On Aug 1, 2010, Dr. Yuelin Zhang’ group published a paper entitled “Activation of Plant Immune Responses by a Gain-of-Function Mutation in an Atypical Receptor-Like Kinase” in Plant Physiology.
In the July issue 2010 of Molecular Plant-Microbe Interactions, Dr. Jian-min Zhou’s lab published an article entitled “Effector-Triggered and Pathogen-Associated Molecular Pattern–Triggered Immunity Differentially Contribute to Basal Resistance to Pseudomonas syringae”.
On July 21, 2010, Dr. Yuelin Zhang’ group published a paper entitled “Arabidopsis resistance protein SNC1 activates immune responses through association with a transcriptional corepressor” in Proc Natl Acad Sci U.S.A.. The paper reported that the TIR-NB-LRR R protein SNC1 activates downstream defense responses through its interacting protein TPR1, a transcriptional corepressor that targets negative regulators of immune responses.
On July 16th, 2010, Dr. Hong Zhang’s lab published a paper in Developmental Biology entitled “Wnt signaling controls temporal identities of seam cells in C. elegans”. This study reveals a novel function of Wnt signaling in controlling the timing of seam cell development in C. elegans.
On July 9, 2010, Dr.Yan Guo’s lab published a paper in Plant Cell entitled “Arabidopsis Cockayne Syndrome A-Like Proteins 1A and 1B Form a Complex with CULLIN4 and Damage DNA Binding Protein 1A and Regulate the Response to UV Irradiation”. The paper reported two Cockayne Syndrome A-Like proteins 1A and 1B form a CUL4-DDB1CSAat1A and B complex and respond to DNA damage and repair process in Arabidopsis.
On June 23, 2010, Dr. Rongwen Xi’s lab published online an article entitled ” TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation” in Development, reporting a novel role of tubular sclerosis complex human disease genes in the maintenance of Drosophila germline stem cells.
On June 23, 2010, Jian-Min Zhou’s lab published online in Plant Cell a paper entitled “A Pseudomonas syringae ADP-ribosyltransferase inhibits Arabidopsis MAP kinase kinases” reporting biochemical mechanism by which the bacterial virulence protein HopF2 assists parasitism.
On Jun. 11th, 2010, Dr. Hong Zhang’s lab published a paper in Cell entitled “C. elegans screen identifies autophagy genes specific to multicellular organisms.”
On June 10, 2010, Dr. Li-Lin Du’s lab published online an article entitled “Global fitness profiling of fission yeast deletion strains by barcode sequencing” in Genome Biology. This article reported the use of deep sequencing for the quantitative phenotyping of a fission yeast deletion mutant library and the identification of mutants hypersensitive to DNA damage treatments and a microtubule depolymerizing drug.
On June 8, 2010, Dr. Xiaochen Wang’s lab published online an article entitled “Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor” in Nature Cell Biology, reporting the first bridging molecule TTR-52 which functions in apoptotic cell removal in C. elgans.
On May 14, 2010, Dr. Yijun Qi’s group at NIBS publishes an article entitled “DNA Methylation Mediated by a MicroRNA Pathway” as the cover story in Molecular Cell. In the article, they reported a new class of microRNAs (miRNAs) that mediate DNA methylation at their target genes.
On May 1, 2010, Dr. Rongwen Xi’s lab published online an article entitled ” Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and non-canonical Wnt signaling” in Genes & Development, reporting a novel mode and mechanism of polycomb genes in controlling stem cell behavior.
On Apr. 28th, Dr. Shaorong Gao’s lab published a research article entitled “Mice cloned from induced pluripotent stem cells (iPSC)” in Biology of Reproduction. In this article, for the first time, viable cloned mice were successfully produced from inducible iPS cells through nuclear transfer approach.
On April 23, 2010, Dr. Yan Guo’s lab published online an article entitled ” The Arabidopsis chaperone J3 regulates the plasma membrane H+-ATPase through interaction with the PKS5 kinase” in Plant Cell, reporting a novel role of chaperone J3 in regulation of plasma membrane H+-ATPase activity response to salt at alkaline pH.
On April 22, 2010, Dr. Jian-min Zhou’s lab published an article entitled “Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector” in Cell Host & Microbe. This paper reported that a group of PBS1-like proteins (PBLs) play a central role in signal integration from multiple immune receptors.
Apr 21, 2010--- Studies from Dr. Feng Shao’s laboratory at National Institute of Biological Sciences, Beijing (NIBS) reveal that enteric bacterial pathogens can thwart the host actin cytoskeleton structure and thereby counteract macrophage phagocytosis by injecting a conserved effector protein that directly targets host RhoGEFs. The work entitled “A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis” is published in The EMBO journal.
On April 7, 2010, Dr. Jijie Chai’s lab published an article entitled “Crystal structure of the FTO protein reveals basis for its substrate specificity” in Nature. This paper reports the crystal structure of FTOΔ31–3-meT complex.
On April 2, 2010, Dr. Bing Zhu’s lab published a paper “Partition of histone H3/H4 tetramers during DNA replication dependent chromatin assembly” in science.

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