Scientists&Research
Xiaochen Wang, Ph.D.
- Information
- Education
- Experience
- Research
- Publication
Xiaochen Wang, Ph.D.
Associate Investigator, NIBS, Beijing, China
Phone：010-80726688
Fax： 010-80726689
E-mail：wangxiaochen@nibs.ac.cn
Education
|
1999 |
Ph.D., National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, China |
|
1992 |
B.S. Microbiology, Department of Microbiology, Shandong University,China |
Professional Experience
|
2011 |
Associate Investigator, National Institute of Biological Sciences, Beijing, China |
|
2006-2011 |
Assistant Investigator, National Institute of Biological Sciences,Beijing, China |
|
1999-2006 |
Postdoctoral research associate, Department of MCD Biology,University of Colorado, Boulder, USA |
|
1998-1999 |
Visiting student, Laboratory of Genetics, Gent University/VIB,Belgium |
Research Description
Phagocytosis of apoptotic cells is an integral part of the cell death program and an important event in tissue remodeling, suppression of inflammation as well as regulation of immune response. Defects in this process contribute to inflammatory diseases and autoimmune disorders.
Using Caenorhabditis elegans as a model system, we take combinatory approaches of genetics, cell biology and biochemistry to identify new genes that control various events of cell corpse clearance including apoptotic cell recognition, internalization and degradation. The characterization and mechanistic studies of these novel players will help us to understand how phagocytosis of apoptotic cell is regulated in worm and in higher organisms like human being.Selected Publications
1. Li X, Chen B, Yoshina S, Cai T, Yang F, Mitani S, and Wang X* (2013). Inactivation of C. elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1mutants. Mol Biol Cell (in press).
2. Huang J, Wang H, Chen Y, Wang X*, and Zhang H*(2012). Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance. Development 139(24), 4613-4622. (*Co-corresponding author)
3. Zhang Y, Wang H, Kage-Nakadai E, Mitani S, and Wang X* (2012). C. elegans
secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment. Curr Biol 22(14), 1276-1284.
4. Liu B, Du H, Rutkowski R, Gartner A, and Wang X* (2012). LAAT-1 is the
lysosomal lysine/arginine transporter that maintains amino acid homeostasis.Science337, 351-354.
5. Kang Y, Zhao D, Liang H, Liu B, Zhang Y, Liu Q, Wang X*, and Liu Y* (2012).
Structural study of TTR-52 reveals the mechanism by which a bridging molecule
mediates apoptotic cell engulfment. Genes Dev. 26(12), 1339-1350.
(*Co-corresponding author)
6. Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, Tian D, Wang X*, Vale RD*, and Ou G* (2012). Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. J Cell Biol 197(1), 27-35.
(Co-corresponding author)
7. Wu YC, Wang X and Xue D (2012). Methods for Studying Programmed Cell Death inC. elegans. in CAENORHABDITIS ELEGANS: CELL BIOLOGY AND PHYSIOLOGY, SECOND EDITION, ELSEVIER ACADEMIC PRESS INC,
8. Guo P, and Wang X* (2010). Rab GTPases act in sequential steps to regulate
phagolysosome formation. Small GTPases 1(3), 1-4 (Invited Extra view).
9. Chen B, Jiang Y, Zeng S, Yan J, Li X, Zhang Y, Zou W, and Wang X* (2010).
Endocytic sorting and recycling require membrane phosphatidylserine asymmetry
maintained by TAT-1/CHAT-1. PLoS Genet 6(12), e1001235.
10. Guo P, Hu T, Zhang J, Jiang S, and Wang X* (2010). Sequential action of
Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during
apoptotic cell degradation. Proc Natl Acad Sci U S A 107, 18016-18021.
11. Wang X*, Li W, Zhao D, Liu B, Shi Y, Chen B, Yang H, Guo P, Geng X, Shang Z,Peden E, Kage-Nakadai E, Mitani S, and Xue D* (2010). Caenorhabditis eleganstransthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nat Cell Biol 12, 655-664. (Co-corresponding author)
12. Tian Y, Li Z, Hu W, Ren, H, Tian, E, Zhao Y, Lu Q, Huang X, Yang P, Li X,Wang X, Kovacs A L, Yu L and Zhang H (2010) C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms. Cell 141(6), 1042-1055.
13. Zou W, Lu Q., Zhao D, Li W, Mapes J, Xie Y, and Wang X* (2009).Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet 5, e1000679.
14. Li W, Zou W, Zhao D, Yan J, Zhu Z, Lu J, and Wang X* (2009). C. elegans Rab
GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5. Development 136, 2445-2455.
15. Lu Q, Zhang Y, Hu T, Guo P, Li W, and Wang X* (2008). C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells. Development 135, 1069-1080.
